The Briton produced an explosive finish in front of 80,000 at Wembley Stadium
Anthony Joshua extended his unbeaten professional record with a sensational stoppage of Alexander Povetkin.
The WBA, WBO and IBF world heavyweight champion overcame a difficult start before ending the contest in the seventh round with a brutal barrage of shots.
Povetkin had started the stronger of the two fighters, showing his power in the first round as he connected with a left hook which left Joshua with a bloody nose.
Joshua remained composed throughout the second round despite bleeding heavily and by its conclusion, his success had led to significant swelling by Povetkin’s right eye.
The champion found his sense of distance during the third, and began to control the range and pace of the fight as his confidence grew.
Povetkin continued to swing and miss with wild left hooks and, in the fourth, began to struggle due to a large cut by his left eye.
A few cagey rounds followed, before Joshua ended the contest in emphatic fashion in the seventh.
After sending the Russian to the canvas with a left-right combination after hurting him with a big right hand, referee Steve Gray intervened to rescue Povetkin once he was back on his feet and unable to defend himself from another hurtful barrage of punches.
The 39-year-old Povetkin, like Joshua an Olympic gold medallist, had previously lost only to Klitschko and over the distance when the great Ukrainian was at his peak.